CBGA (Cannabigerolic acid) is the parent molecule from which other cannabinoids are synthesized. the acid form of Cannabigerol (CBG), one of more than 120 identified cannabinoid compounds found in the Cannabis plant. Cannabigerol is a minor constituent of cannabis.During growth, most of the cannabigerol is converted into other cannabinoids, primarily tetrahydrocannabinol (THC) or cannabidiol (CBD), leaving about 1% cannabigerol in the plant.
Cannabigerol is currently being studied to determine its pharmacological properties and potential effects in disease conditions. Contrary to the major psychoactive cannabinoid THC, cannabigerol antagonizes CB1 receptors and is both a alpha2-adrenoceptor agonist and moderate 5HT1A receptor antagonist. Cannabigerol displays CB1andCB2 binding affinity. Additionally, cannabigerol has been evaluated in laboratory models of colitis.
Cannabigerol is not scheduled by the UN Convention on Psychotropic Substances. In the United States, it is not a controlled substance under the Controlled Substances Act unless it is produced from parts of the cannabis plant, which is scheduled.
THCA (Δ9-tetrahydrocannabinolic acid) is a precursor of Δ9-tetrahydrocannabinol (THC), one of the possible active components of cannabis. THCA is not scheduled at the federal level in the United States, but it is possible that THCA could legally be considered an analog of THC and sales or possession could potentially be prosecuted under the Federal Analogue Act. In practice, because THCA decarboxylates to form THC, no real sample of purified THCA will be completely free of THC. Thus, any laboratory analysis of THCA using any technique involving significant heat will generate THC in the handling and analytical process. It is unstable, and slowly decarboxylates into THC during storage, and the THC itself slowly degrades to cannabinol, found with potential immunosuppressive and anti-inflammatoryactivities. When heated or burned, as when cannabis is smoked or included in baked goods, the decarboxylation is rapid but not complete; THCA is detectable in people who smoke or otherwise consume cannabis.
While it is true that the types of cannabis that have been cultivated for fiber or grain production, in countries like Canada and China, have had quite small amounts of THC relatively, only recently did governments begin to define industrial hemp by it’s THC content. For example, in the U.S., hemp and hemp-derived products must contain less than 0.3% THC by dry weight. By contrast, Cannabis strains that are cultivated for their THC content, can have 20-30% THC by dry weight.